wow ok - sorry - i hadn't realized this was an Epson printer. Yeah; 5.3 with that registry fix (as documented in KB VMware KB: Epson printers become unresponsive in VMware Horizon View ) is definately your next step! We need to interact with the Epson device driver in a different way to other devices, because the Epson drivers seem to work in a non standard way.
We did some major changes to the way USB works in View 5.1, and as such really going back to 5.0 isn't the right solution here.
Lets try the 5.3 agent, with that registry fix - and then move forward from there. Im sure we will get there in the end!
cheers
peterB